Accumulation of ‘toxins’ in brain is why thinking hard is tiring, study suggests

Scientists discovered that when intense mental work is carried out over several hours, it causes potentially toxic by-products to build up.

11 August 2022

A long, hard day of thinking can sometimes feel as exhausting as a day of physical labour, and now scientists say they know why.

Researchers suggest their findings indicate the reason people feel mentally exhausted, and not drowsy, from intense thinking is not just in their heads.

According to the study, when intense mental work is carried out over several hours, it causes potentially toxic by-products to build up in the part of the brain known as the prefrontal cortex.

This, in turn, alters a person’s control over decisions, so they shift toward actions that require no effort or waiting as mental fatigue sets in.

This fatigue tells the brain to shut down in order to save itself.

Mathias Pessiglione of Pitie-Salpetriere University in France, said: “Influential theories suggested that fatigue is a sort of illusion cooked up by the brain to make us stop whatever we are doing and turn to a more gratifying activity.

“But our findings show that cognitive work results in a true functional alteration – accumulation of noxious substances – so fatigue would indeed be a signal that makes us stop working but for a different purpose: to preserve the integrity of brain functioning.”

The researchers monitored brain chemistry over the course of a workday, looking at two groups of people: those who needed to think hard and those who had relatively easier cognitive tasks.

In the group doing hard work they saw signs of fatigue, including reduced pupil dilation.

People in that group also made choices toward options proposing rewards at short delay with little effort.

Critically, the researchers say, they also had higher levels of a chemical called glutamate in the brain’s prefrontal cortex.

Together with earlier evidence, the authors say it supports the notion that glutamate accumulation makes further activation of this part of the brain costly, such that cognitive control is more difficult after a mentally tough workday.

The findings are published in the Current Biology journal.

More from Perspective

Get a free copy of our print edition


Leave a Reply

Your email address will not be published. Required fields are marked *

Fill out this field
Fill out this field
Please enter a valid email address.
You need to agree with the terms to proceed

Your email address will not be published. The views expressed in the comments below are not those of Perspective. We encourage healthy debate, but racist, misogynistic, homophobic and other types of hateful comments will not be published.