The pressure is mounting on Prime Minister Sir Keir Starmer, though he has vowed to fight any challenge to his position.
Wes Streeting’s resignation as health secretary has thrown the future of the Labour leadership into further doubt after days of mounting speculation about the prospect of a challenge to Sir Keir Starmer’s position.
Here the Press Association looks at what could happen next:
– Will a Labour leadership contest be triggered?
This would depend on Mr Streeting, or another leadership hopeful within the parliamentary party, securing the backing of the 81 Labour MPs required to mount a challenge. It was unclear on Thursday whether he had reached this threshold, and his resignation letter appeared to imply he would not be triggering an immediate contest.
– Who else could stand in any contest, and when?
In the letter, Mr Streeting said any contest should be “broad”, suggesting an openness to Greater Manchester Mayor Andy Burnham standing in any race – although some have interpreted this as a sign the ex-minister does not have the numbers to mount a challenge.
Compounding the uncertainty are the various logistical obstacles Mr Burnham, who is seen as a party favourite to replace Sir Keir, would need to clear before standing in any race.
His path back to Westminster is complicated by his need to fight and win a by-election first, which would take weeks, and despite briefings suggesting a Commons seat may have been identified for him, no Labour MPs have voiced a willingness to stand down for him.
Speculation has also intensified that Sir Keir’s former deputy Angela Rayner could throw her hat in the ring after she said she was cleared of tax misconduct in an HMRC investigation that had previously overshadowed her prospects.
She denied having struck a pact with Mr Burnham that would see him lined up as her successor and indicated she could run in any future contest, telling ITV on Thursday: “I am not doing deals.”
Meanwhile, Sir Keir himself insisted he would fight any challenge to his leadership on Monday – a position which Downing Street reiterated on Thursday.
Armed forces minister Al Carns and Energy Secretary Ed Miliband have also been tipped as potential candidates.
– How would a Labour leadership contest work?
After a leadership hopeful nails down 81 backers in the Commons, candidates are then put for a vote to party members, who rank them in order of preference.
A contender is declared the winner if they get more than 50% of first preferences, and this usually happens though a process of elimination during rounds of voting, the timetable for which is set by Labour’s ruling NEC.
– Can Sir Keir hold on to power?
This depends heavily on the movements of his wider Cabinet.
Sir Keir dug in on Tuesday amid mounting calls from Labour MPs for his resignation, telling his senior ministers there is a formal process for challenging a Labour leader that had not been triggered.
This is true, but without the confidence of his Cabinet, it would be all but impossible for him to continue to govern.
When Boris Johnson’s authority collapsed in 2022, he sought to cling on to power by replacing senior ministers after they had quit with loyalist MPs.
But it was a matter of days after the first Cabinet minister stood down that he was forced to announce his resignation as Tory leader outside No 10.

